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European Journal of Obstetrics & Gynecology and Reproductive Biology , 179, 1-7

Diagnosis is primarily clinical, based on the presence of specific tender points and a history of widespread pain

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Researchers studying gastrointestinal effects have used both acute (single-dose) and chronic (7-14 day) protocols, with efficacy observed in both paradigms

As the insulin receptor is expressed in all cell types and insulin signaling mediates diverse cellular functions, the detailed insulin function of each tissue has been extensively studied using tissue-specific Insr knockout mice 3,5 , in which Insr expression is almost completely disrupted in a specific cell type